• Nature Reviews Drug Discovery
  • NIH Research Matters
  • Press Release (Malaria)
  • Press Release (IKK2)
  • Nature Cell Biol. (IKK2)
  • Press Release/Staph
  • C&EN News: Diterpene Cyclase
  • Nature Chem. Biol. on CrtM
  • 2011 Biophysical Society Award
  • C&EN News on 4Fe4S Cluster
  • Accounts of Chemical Research
  • PNAS: IspG
  • Jordan Gets ACS Scholarship Award
  • IspH PNAS in Microbe Magazine
  • Illinois News Bureau
  • RSC Award
  • C&EN
  • Chagas Clinical Results in Microbe Magazine
  • Our Pre-clinical Chagas Paper
  • Naked Scientists Podcast about Staph inhibitor
  • Nature Reviews Drug Discovery
  • New England Journal of Medicine


    Welcome Bienvenidos Welcome
    Swagatam Swagatam Welcome
    Our interests are to use XRD, computational chemistry, NMR, and synthesis to develop new antibiotics, anti-parasitics, and anti-cancer drugs.

    • Anti-Parasitics
    • NRC Rankings
    • Membrane NMR
    • Julio Urbina T. cruzi
    • Quantum Proteins
    • Bisphosphonate Mechanism
    • NO-Heme DFT
    • Dual Inhibitors
    • CrtM Mechanism
    • IPPI
    • Anti-Bacterials
    • Fuel Cell EC NMR
    • Pt-Rh EC NMR
    • Structure Refinement
    • UPPS Structure
    • Malaria No More
    • Actonel Chagas
    • LytB(IspH) Structure
    • Bone-Binding
    • Inorganic Solisd

    Latest 10 Publications


    Y.L. Liu, S. Lindert, W. Zhu, K. Wang, J.A. McCammon, E. Oldfield
    Taxodione and Arenarone Inhibit Farnesyl Diphosphate Synthase by Binding to the Isopentenyl Diphosphate Site
    PNAS, 111, E2530-9, (2014), doi: 10.1073/pnas.1409061111.


    N. Shang, Q. Li, T.P. Ko, H.C. Chan, J. Li, Y. Zheng, C.H. Huang, F. Ren, C.C. Chen, Z. Zhu, M. Galizzi, Z.H. Li, C.A. Rodrigues-Poveda, D. Gonzalez-Pacanowska, P. Veiga-Santos, T.M. de Carvalho, W. de Souza, J.A. Urbina, A.H. Wang, R. Docampo, K. Li, Y.L. Liu, E. Oldfield, R.T. Guo
    Squalene synthase as a target for chagas disease therapeutics
    PLoS Pathog, 10(5):e1004114, (2014). doi: 10.1371/journal.ppat.1004114.


    I. Span, K. Wang, W. Eisenreich, A. Bacher, Y. Zhang , E. Oldfield, M. Groll
    Insights into the binding of pyridines to the iron–aulfur enzyme IspH
    JACS, (2014), doi: 10.1021/ja501127j.


    W. Sinko, Y. Wang, W. Zhu, Y. Zhang, F. Feixas, C. Cox, D. A. Mitchell, E. Oldfield ,J. A. McCammon
    Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads
    J Med Chem, (2014), doi: 10.1021/jm5004649.


    F. Guerra, K. Wang, J. Li, W. Wang, Y.L. Liu, S. Amin, E. Oldfield.
    Inhibition of the 4Fe–4S proteins IspG and IspH: an EPR, ENDOR and HYSCORE investigation
    Chem Sci, 5, 1642-1649, (2014), doi: 10.1039/C3SC53301H.


    Aripirala S, Gonzalez-Pacanowska D, Oldfield E, Kaiser M, Amzel LM, Gabelli SB.
    Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates.
    Acta Crystallogr D Biol Crystallogr, 70(Pt 3), 802-10, (2014), doi: 10.1107/S1399004713033221.


    Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes FL, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu YL, Molohon KJ, Orlean P, Mitchell DA, Freitas-Junior LH, Ren F, Sun H, Jiang T, Li Y, Guo RT, Cole ST, Gennis B, Crick DC, Oldfield E.
    Multi-Target Drug Discovery for Tuberculosis and Other Infectious Diseases.
    J Med Chem, (2014), doi: 10.1021/jm500131s.


    Benaim G, Casanova P, Hernandez-Rodriguez V, Mujica-Gonzalez S, Parra-Gimenez N, Plaza-Rojas L, Concepcion JL, Liu YL, Oldfield E, Paniz-Mondolfi A, Suarez AI.
    Dronedarone, an Amiodarone Analog with Improved Anti-Leishmania mexicana Efficacy.
    Antimicrob Agents Chemother, 58(4), 2295-303, (2014), doi: 10.1128/AAC.01240-13.


    W. Wang, E. Oldfield.
    Bioorganometallic Chemistry with IspG and IspH: Structure, Function, and Inhibition of the [Fe4 S4 ] Proteins Involved in Isoprenoid Biosynthesis.
    Angew Chem Int Ed Engl. (2014) doi: 10.1002/anie.201306712.


    H.C. Chan, X. Feng, T.P. Ko, C.H. Huang, Y. Hu, Y. Zheng, S. Bogue, C. Nakano, T. Hoshino, L. Zhang, P. Lv, W. Liu, D.C. Crick, P.H. Liang, A.H. Wang, E. Oldfield, R.T. Guo.
    Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis.
    J Am Chem Soc, 136(7), 2892-6, (2014). doi: 10.1021/ja413127v.

    (c) 2010-2012 Research Group of Professor Eric Oldfield
    University of Illinois at Urbana-Champaign

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