NEWS

  • Nature Reviews Drug Discovery
  • NIH Research Matters
  • Press Release (Malaria)
  • Press Release (IKK2)
  • Nature Cell Biol. (IKK2)
  • Press Release/Staph
  • C&EN News: Diterpene Cyclase
  • Nature Chem. Biol. on CrtM
  • 2011 Biophysical Society Award
  • C&EN News on 4Fe4S Cluster
  • Accounts of Chemical Research
  • PNAS: IspG
  • Jordan Gets ACS Scholarship Award
  • IspH PNAS in Microbe Magazine
  • Illinois News Bureau
  • RSC Award
  • C&EN
  • Chagas Clinical Results in Microbe Magazine
  • Our Pre-clinical Chagas Paper
  • Naked Scientists Podcast about Staph inhibitor
  • Nature Reviews Drug Discovery
  • New England Journal of Medicine



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    Welcome Bienvenidos Welcome
    Swagatam Swagatam Welcome
     
    Our interests are to use XRD, computational chemistry, NMR, and synthesis to develop new antibiotics, anti-parasitics, and anti-cancer drugs.

    • Anti-Parasitics
    • NRC Rankings
    • Membrane NMR
    • Julio Urbina T. cruzi
    • Quantum Proteins
    • Bisphosphonate Mechanism
    • NO-Heme DFT
    • Dual Inhibitors
    • CrtM Mechanism
    • IPPI
    • Anti-Bacterials
    • Fuel Cell EC NMR
    • Pt-Rh EC NMR
    • Structure Refinement
    • UPPS Structure
    • Malaria No More
    • Actonel Chagas
    • LytB(IspH) Structure
    • Bone-Binding
    • Inorganic Solisd






    Latest 10 Publications

    397

    Oldfield E, Feng X.
    Resistance-resistant antibiotics.
    Trends Pharmacol Sci. Nov 5;35(12):664-674 (2014)doi: 10.1016/j.tips.2014.10.007. & Podcast

    396

    Xia Y, Liu YL, Xie Y, Zhu W, Guerra F, Shen S, Yeddula N, Fischer W, Low W, Zhou X, Zhang Y, Oldfield E, Verma IM.
    A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin.
    Sci Transl Med. Nov 19;6(263):263ra161. (2014) doi: 10.1126/scitranslmed.3010382. Podcast & Press release

    395

    Han X, Chen CC, Kuo CJ, Huang CH, Zheng Y, Ko TP, Zhu Z, Feng X, Wang K, Oldfield E, Wang AH, Liang PH, Guo RT, Ma Y.
    Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms.
    Proteins. 2015 Jan;83(1):37-45. doi: 10.1002/prot.24618.

    394

    Kim MO, Feng X, Feixas F, Zhu W, Lindert S, Bogue S, Sinko W, de Oliveira C, Rao G, Oldfield E, McCammon JA.
    A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery.
    Chem Biol Drug Des. Oct 28. (2014) doi: 10.1111/cbdd.12463.

    393

    Feng X, Hu Y, Zheng Y, Zhu W, Li K, Huang CH, Ko TP, Ren F, Chan HC, Nega M, Bogue S, López D, Kolter R, Götz F, Guo RT, Oldfield E.
    Structural and Functional Analysis of Bacillus subtilis YisP Reveals a Role of Its Product in Biofilm Production.
    Chem Biol, 21(11):1557-63 (2014), doi: 10.1016/j.chembiol.2014.08.018

    392

    Liu W, Feng X, Zheng Y, Huang CH, Nakano C, Hoshino T, Bogue S, Ko TP, Chen CC, Cui Y, Li J, Wang I, Hsu ST, Oldfield E, Guo RT.
    Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum.
    Sci Rep, Oct 1;4:6214 (2014), Free PMC Article.

    391

    Khade RL, Fan W, Ling Y, Yang L, Oldfield E, Zhang Y.
    Iron porphyrin carbenes as catalytic intermediates: structures, Mössbauer and NMR spectroscopic properties, and bonding.
    Angew Chem Int Ed Engl. Jul 14;53(29):7574-8, (2014), DOI: 10.1002/anie.201402472.

    390

    Y.L. Liu, S. Lindert, W. Zhu, K. Wang, J.A. McCammon, E. Oldfield
    Taxodione and Arenarone Inhibit Farnesyl Diphosphate Synthase by Binding to the Isopentenyl Diphosphate Site
    PNAS, 111, E2530-9, (2014), doi: 10.1073/pnas.1409061111.

    389

    N. Shang, Q. Li, T.P. Ko, H.C. Chan, J. Li, Y. Zheng, C.H. Huang, F. Ren, C.C. Chen, Z. Zhu, M. Galizzi, Z.H. Li, C.A. Rodrigues-Poveda, D. Gonzalez-Pacanowska, P. Veiga-Santos, T.M. de Carvalho, W. de Souza, J.A. Urbina, A.H. Wang, R. Docampo, K. Li, Y.L. Liu, E. Oldfield, R.T. Guo
    Squalene synthase as a target for chagas disease therapeutics
    PLoS Pathog, 10(5):e1004114, (2014). doi: 10.1371/journal.ppat.1004114.

    388

    I. Span, K. Wang, W. Eisenreich, A. Bacher, Y. Zhang , E. Oldfield, M. Groll
    Insights into the binding of pyridines to the iron–aulfur enzyme IspH
    JACS, (2014), doi: 10.1021/ja501127j.

    (c) 2010-2012 Research Group of Professor Eric Oldfield
    University of Illinois at Urbana-Champaign

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