• Nature Reviews Drug Discovery
  • NIH Research Matters
  • Press Release (Malaria)
  • Press Release (IKK2)
  • Nature Cell Biol. (IKK2)
  • Press Release/Staph
  • C&EN News: Diterpene Cyclase
  • Nature Chem. Biol. on CrtM
  • 2011 Biophysical Society Award
  • C&EN News on 4Fe4S Cluster
  • Accounts of Chemical Research
  • PNAS: IspG
  • Jordan Gets ACS Scholarship Award
  • IspH PNAS in Microbe Magazine
  • Illinois News Bureau
  • RSC Award
  • C&EN
  • Chagas Clinical Results in Microbe Magazine
  • Our Pre-clinical Chagas Paper
  • Naked Scientists Podcast about Staph inhibitor
  • Nature Reviews Drug Discovery
  • New England Journal of Medicine


    Welcome Bienvenidos Welcome
    Swagatam Swagatam Welcome
    Our interests are to use XRD, computational chemistry, NMR, and synthesis to develop new antibiotics, anti-parasitics, and anti-cancer drugs.

    • Anti-Parasitics
    • NRC Rankings
    • Membrane NMR
    • Julio Urbina T. cruzi
    • Quantum Proteins
    • Bisphosphonate Mechanism
    • NO-Heme DFT
    • Dual Inhibitors
    • CrtM Mechanism
    • IPPI
    • Anti-Bacterials
    • Fuel Cell EC NMR
    • Pt-Rh EC NMR
    • Structure Refinement
    • UPPS Structure
    • Malaria No More
    • Actonel Chagas
    • LytB(IspH) Structure
    • Bone-Binding
    • Inorganic Solisd

    Latest 10 Publications


    Liu YL, Cao R, Wang Y, Oldfield E.
    Farnesyl Diphosphate Synthase Inhibitors With Unique Ligand-Binding Geometries
    ACS Med. Chem. Lett., Article ASAP. doi: 10.1021/ml500528x.


    Veiga-Santos P, Li K, Lameira L, de Carvalho TM, Huang G, Galizzi M, Shang N, Li Q, Gonzalez-Pacanowska D, Hernandez-Rodriguez V, Benaim G, Guo RT, Urbina JA, Docampo R, de Souza W, Oldfield E.
    SQ109: A New Drug Lead for Chagas Disease.
    Antimicrob Agents Chemother. 2015 Jan 12. pii: AAC.03972-14. [Epub ahead of print]. doi:10.1128/AAC.03972-14.


    Zhu W, Wang Y, Li K, Gao J, Huang CH, Chen CC, Ko TP, Zhang Y, Guo RT, Oldfield E
    Antibacterial Drug Leads: DNA and Enzyme Multitargetting.
    J Med Chem. 2015 Jan 22. [Epub ahead of print]. doi: 10.1021/jm501449u.


    Oldfield E, Feng X.
    Resistance-resistant antibiotics.
    Trends Pharmacol Sci. Nov 5;35(12):664-674 (2014)doi: 10.1016/ & Podcast


    Xia Y, Liu YL, Xie Y, Zhu W, Guerra F, Shen S, Yeddula N, Fischer W, Low W, Zhou X, Zhang Y, Oldfield E, Verma IM.
    A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin.
    Sci Transl Med. Nov 19;6(263):263ra161. (2014) doi: 10.1126/scitranslmed.3010382. Podcast & Press release


    Han X, Chen CC, Kuo CJ, Huang CH, Zheng Y, Ko TP, Zhu Z, Feng X, Wang K, Oldfield E, Wang AH, Liang PH, Guo RT, Ma Y.
    Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms.
    Proteins. 2015 Jan;83(1):37-45. doi: 10.1002/prot.24618.


    Kim MO, Feng X, Feixas F, Zhu W, Lindert S, Bogue S, Sinko W, de Oliveira C, Rao G, Oldfield E, McCammon JA.
    A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery.
    Chem Biol Drug Des. Oct 28. (2014) doi: 10.1111/cbdd.12463.


    Feng X, Hu Y, Zheng Y, Zhu W, Li K, Huang CH, Ko TP, Ren F, Chan HC, Nega M, Bogue S, López D, Kolter R, Götz F, Guo RT, Oldfield E.
    Structural and Functional Analysis of Bacillus subtilis YisP Reveals a Role of Its Product in Biofilm Production.
    Chem Biol, 21(11):1557-63 (2014), doi: 10.1016/j.chembiol.2014.08.018


    Liu W, Feng X, Zheng Y, Huang CH, Nakano C, Hoshino T, Bogue S, Ko TP, Chen CC, Cui Y, Li J, Wang I, Hsu ST, Oldfield E, Guo RT.
    Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum.
    Sci Rep, Oct 1;4:6214 (2014), Free PMC Article.


    Khade RL, Fan W, Ling Y, Yang L, Oldfield E, Zhang Y.
    Iron porphyrin carbenes as catalytic intermediates: structures, Mössbauer and NMR spectroscopic properties, and bonding.
    Angew Chem Int Ed Engl. Jul 14;53(29):7574-8, (2014), DOI: 10.1002/anie.201402472.

    (c) 2010-2012 Research Group of Professor Eric Oldfield
    University of Illinois at Urbana-Champaign

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