• Nature Reviews Drug Discovery
  • NIH Research Matters
  • Press Release (Malaria)
  • Press Release (IKK2)
  • Nature Cell Biol. (IKK2)
  • Press Release/Staph
  • C&EN News: Diterpene Cyclase
  • Nature Chem. Biol. on CrtM
  • 2011 Biophysical Society Award
  • C&EN News on 4Fe4S Cluster
  • Accounts of Chemical Research
  • PNAS: IspG
  • Jordan Gets ACS Scholarship Award
  • IspH PNAS in Microbe Magazine
  • Illinois News Bureau
  • RSC Award
  • C&EN
  • Chagas Clinical Results in Microbe Magazine
  • Our Pre-clinical Chagas Paper
  • Naked Scientists Podcast about Staph inhibitor
  • Nature Reviews Drug Discovery
  • New England Journal of Medicine


    Welcome Bienvenidos Welcome
    Swagatam Swagatam Welcome
    Our interests are to use XRD, computational chemistry, NMR, and synthesis to develop new antibiotics, anti-parasitics, and anti-cancer drugs.

    • Anti-Parasitics
    • NRC Rankings
    • Membrane NMR
    • Julio Urbina T. cruzi
    • Quantum Proteins
    • Bisphosphonate Mechanism
    • NO-Heme DFT
    • Dual Inhibitors
    • CrtM Mechanism
    • IPPI
    • Anti-Bacterials
    • Fuel Cell EC NMR
    • Pt-Rh EC NMR
    • Structure Refinement
    • UPPS Structure
    • Malaria No More
    • Actonel Chagas
    • LytB(IspH) Structure
    • Bone-Binding
    • Inorganic Solisd

    Latest 10 Publications


    Schwalen CJ, Feng X, Liu W, O-Dowd B, Ko TP, Shin CJ, Guo RT, Mitchell DA, Oldfield E.
    Head-to-Head Prenyl Synthases in Pathogenic Bacteria.
    Chembiochem. 2017 Jun 1;18(11):985-991. DOI: 10.1002/cbic.201700099.


    ODowd B, Williams S, Wang H, No JH, Rao G, Wang W, McCammon JA, Cramer SP, Oldfield E.
    Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors.
    Chembiochem. 2017 May 18;18(10):914-920. DOI: 10.1002/cbic.201700052.


    Mohammad H, Younis W, Chen L, Peters CE, Pogliano J, Pogliano K, Cooper B, Zhang J, Mayhoub A, Oldfield E, Cushman M, Seleem MN.
    Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci.
    J Med Chem. 2017 Mar 23;60(6):2425-2438. DOI: 10.1021/acs.jmedchem.6b01780.


    Wang Y, Desai J, Zhang Y, Malwal SR, Shin CJ, Feng X, Sun H, Liu G, Guo RT, Oldfield E.
    Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase.
    ChemMedChem. 2016 Oct 19;11(20):2311-2319. DOI: 10.1002/cmdc.201600342.


    Desai J, Wang Y, Wang K, Malwal SR, Oldfield E.
    Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth.
    ChemMedChem. 2016 Oct 6;11(19):2205-2215. DOI: 10.1002/cmdc.201600343.


    G Ricci C, Liu YL, Zhang Y, Wang Y, Zhu W, Oldfield E, McCammon JA.
    Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
    Biochemistry. 2016 Sep 13;55(36):5180-90. DOI: 10.1021/acs.biochem.6b00398.


    Bai Y, Feng X, Xing H, Xu Y, Kim BK, Baig N, Zhou T, Gewirth AA, Lu Y, Oldfield E, Zimmerman SC.
    A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "Click" Reactions in Water and in Cells.
    J Am Chem Soc. 2016 Sep 7;138(35):11077-80. DOI: 10.1021/jacs.6b04477


    García-García V, Oldfield E, Benaim G.
    Inhibition of Leishmania mexicana Growth by the Tuberculosis Drug SQ109.
    Antimicrob Agents Chemother. 2016 Sep 23;60(10):6386-9. DOI: 10.1128/AAC.00945-16.


    Desai J, Liu YL, Wei H, Liu W, Ko TP, Guo RT, Oldfield E.
    Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase.
    ChemMedChem. 2016 Sep 6;11(17):1915-23. DOI: 10.1002/cmdc.201600311.


    Rao G, Oldfield E.
    Structure and Function of Four Classes of the 4Fe-4S Protein, IspH.
    Biochemistry. 2016 Jul 26;55(29):4119-29. DOI: 10.1021/acs.biochem.6b00474.

    (c) 2010-2015 Research Group of Professor Eric Oldfield
    University of Illinois at Urbana-Champaign

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