NEWS

  • Nature Reviews Drug Discovery
  • NIH Research Matters
  • Press Release (Malaria)
  • Press Release (IKK2)
  • Nature Cell Biol. (IKK2)
  • Press Release/Staph
  • C&EN News: Diterpene Cyclase
  • Nature Chem. Biol. on CrtM
  • 2011 Biophysical Society Award
  • C&EN News on 4Fe4S Cluster
  • Accounts of Chemical Research
  • PNAS: IspG
  • Jordan Gets ACS Scholarship Award
  • IspH PNAS in Microbe Magazine
  • Illinois News Bureau
  • RSC Award
  • C&EN
  • Chagas Clinical Results in Microbe Magazine
  • Our Pre-clinical Chagas Paper
  • Naked Scientists Podcast about Staph inhibitor
  • Nature Reviews Drug Discovery
  • New England Journal of Medicine



  •  

    Welcome Bienvenidos Welcome
    Swagatam Swagatam Welcome
     
    Our interests are to use XRD, computational chemistry, NMR, and synthesis to develop new antibiotics, anti-parasitics, and anti-cancer drugs.

    • Anti-Parasitics
    • NRC Rankings
    • Membrane NMR
    • Julio Urbina T. cruzi
    • Quantum Proteins
    • Bisphosphonate Mechanism
    • NO-Heme DFT
    • Dual Inhibitors
    • CrtM Mechanism
    • IPPI
    • Anti-Bacterials
    • Fuel Cell EC NMR
    • Pt-Rh EC NMR
    • Structure Refinement
    • UPPS Structure
    • Malaria No More
    • Actonel Chagas
    • LytB(IspH) Structure
    • Bone-Binding
    • Inorganic Solisd






    Latest 10 Publications

    386

    F. Guerra, K. Wang, J. Li, W. Wang, Y.L. Liu, S. Amin, E. Oldfield.
    Inhibition of the 4Fe–4S proteins IspG and IspH: an EPR, ENDOR and HYSCORE investigation
    Chem Sci, 5, 1642-1649, (2014), doi: 10.1039/C3SC53301H.

    385

    Aripirala S, Gonzalez-Pacanowska D, Oldfield E, Kaiser M, Amzel LM, Gabelli SB.
    Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates.
    Acta Crystallogr D Biol Crystallogr, 70(Pt 3), 802-10, (2014), doi: 10.1107/S1399004713033221.

    384

    Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes FL, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu YL, Molohon KJ, Orlean P, Mitchell DA, Freitas-Junior LH, Ren F, Sun H, Jiang T, Li Y, Guo RT, Cole ST, Gennis B, Crick DC, Oldfield E.
    Multi-Target Drug Discovery for Tuberculosis and Other Infectious Diseases.
    J Med Chem, (2014), doi: 10.1021/jm500131s.

    383

    Benaim G, Casanova P, Hernandez-Rodriguez V, Mujica-Gonzalez S, Parra-Gimenez N, Plaza-Rojas L, Concepcion JL, Liu YL, Oldfield E, Paniz-Mondolfi A, Suarez AI.
    Dronedarone, an Amiodarone Analog with Improved Anti-Leishmania mexicana Efficacy.
    Antimicrob Agents Chemother, 58(4), 2295-303, (2014), doi: 10.1128/AAC.01240-13.

    382

    W. Wang, E. Oldfield.
    Bioorganometallic Chemistry with IspG and IspH: Structure, Function, and Inhibition of the [Fe4 S4 ] Proteins Involved in Isoprenoid Biosynthesis.
    Angew Chem Int Ed Engl. (2014) doi: 10.1002/anie.201306712.

    381

    H.C. Chan, X. Feng, T.P. Ko, C.H. Huang, Y. Hu, Y. Zheng, S. Bogue, C. Nakano, T. Hoshino, L. Zhang, P. Lv, W. Liu, D.C. Crick, P.H. Liang, A.H. Wang, E. Oldfield, R.T. Guo.
    Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis.
    J Am Chem Soc, 136(7), 2892-6, (2014). doi: 10.1021/ja413127v.

    380

    P.D. Ziniel, J. Desai, C.L. Cass, C. Gatto, E. Oldfield, D.L. Williams.
    Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni.
    Antimicrob Agents Chemother, 57(12), 5969-76, (2013). doi: 10.1128/AAC.00699-13.

    379

    Y. Zhang, W. Zhu, Y.L. Liu, H. Wang, K. Wang, K. Li, J.H. No, L. Ayong, A. Gulati, R. Pang, L. Freitas-Junior, C. T Morita, E. Oldfield.
    Chemo-Immunotherapeutic Antimalarials Targeting Isoprenoid Biosynthesis
    ACS Med Chem Lett, 4(4), 423-427, (2013). doi: 10.1021/ml4000436.

    378

    J. Li, K. Wang, T.I. Smirnova, R.L. Khade, Y. Zhang, E. Oldfield.
    Isoprenoid Biosynthesis: Ferraoxetane or Allyl Anion Mechanism for IspH Catalysis?
    Angew. Chem. Int. Ed., 52, 1, (2013). doi: 10.1002/anie.201302343

    377

    S. Lindert, W. Zhu, Y.L. Liu, R. Pang, E. Oldfield, J.A. McCammon.
    Farnesyl diphosphate synthase inhibitors from in silico screening.
    Chem. Biol. Drug Des. (2013). doi: 10.1111/cbdd.12121.

    (c) 2010-2012 Research Group of Professor Eric Oldfield
    University of Illinois at Urbana-Champaign

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