• Nature Reviews Drug Discovery
  • NIH Research Matters
  • Press Release (Malaria)
  • Press Release (IKK2)
  • Nature Cell Biol. (IKK2)
  • Press Release/Staph
  • C&EN News: Diterpene Cyclase
  • Nature Chem. Biol. on CrtM
  • 2011 Biophysical Society Award
  • C&EN News on 4Fe4S Cluster
  • Accounts of Chemical Research
  • PNAS: IspG
  • Jordan Gets ACS Scholarship Award
  • IspH PNAS in Microbe Magazine
  • Illinois News Bureau
  • RSC Award
  • C&EN
  • Chagas Clinical Results in Microbe Magazine
  • Our Pre-clinical Chagas Paper
  • Naked Scientists Podcast about Staph inhibitor
  • Nature Reviews Drug Discovery
  • New England Journal of Medicine


    Welcome Bienvenidos Welcome
    Swagatam Swagatam Welcome
    Our interests are to use XRD, computational chemistry, NMR, and synthesis to develop new antibiotics, anti-parasitics, and anti-cancer drugs.

    • Anti-Parasitics
    • NRC Rankings
    • Membrane NMR
    • Julio Urbina T. cruzi
    • Quantum Proteins
    • Bisphosphonate Mechanism
    • NO-Heme DFT
    • Dual Inhibitors
    • CrtM Mechanism
    • IPPI
    • Anti-Bacterials
    • Fuel Cell EC NMR
    • Pt-Rh EC NMR
    • Structure Refinement
    • UPPS Structure
    • Malaria No More
    • Actonel Chagas
    • LytB(IspH) Structure
    • Bone-Binding
    • Inorganic Solisd

    Latest 10 Publications


    Gao J*, Ko TP*, Chen L*, Malwal SR*, Zhang J, Hu X, Qu F, Liu W, Huang JW, Cheng YS, Chen CC, Yang Y, Zhang Y, Oldfield E, Guo RT.
    "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase.
    Angew Chem Int Ed Engl. 2018 Jan 15;57(3):683-687. DOI: 10.1002/anie.201710185


    X Zhou, Y Gu, H Xiao, N Kang, Y Xie, G Zhang, Y Shi, X Hu, E Oldfield, X Zhang, Yonghui Zhang
    Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells
    Front. Immunol., 24 October 2017.


    Rao G, Bansal S, Law WX, O Dowd B, Dikanov SA, Oldfield E.
    Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase.
    Biochemistry. 2017 Jul 25;56(29):3770-3779. DOI: 10.1021/acs.biochem.7b00308


    Boulmier A, Feng X, Oms O, Mialane P, Rivière E, Shin CJ, Yao J, Kubo T, Furuta T, Oldfield E, Dolbecq A.
    Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results.
    Inorg Chem. 2017 Jul 3;56(13):7558-7565. DOI: 10.1021/acs.inorgchem.7b01114


    Schwalen CJ, Feng X, Liu W, O-Dowd B, Ko TP, Shin CJ, Guo RT, Mitchell DA, Oldfield E.
    Head-to-Head Prenyl Synthases in Pathogenic Bacteria.
    Chembiochem. 2017 Jun 1;18(11):985-991. DOI: 10.1002/cbic.201700099.


    ODowd B, Williams S, Wang H, No JH, Rao G, Wang W, McCammon JA, Cramer SP, Oldfield E.
    Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors.
    Chembiochem. 2017 May 18;18(10):914-920. DOI: 10.1002/cbic.201700052.


    Mohammad H, Younis W, Chen L, Peters CE, Pogliano J, Pogliano K, Cooper B, Zhang J, Mayhoub A, Oldfield E, Cushman M, Seleem MN.
    Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci.
    J Med Chem. 2017 Mar 23;60(6):2425-2438. DOI: 10.1021/acs.jmedchem.6b01780.


    Wang Y, Desai J, Zhang Y, Malwal SR, Shin CJ, Feng X, Sun H, Liu G, Guo RT, Oldfield E.
    Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase.
    ChemMedChem. 2016 Oct 19;11(20):2311-2319. DOI: 10.1002/cmdc.201600342.


    Desai J, Wang Y, Wang K, Malwal SR, Oldfield E.
    Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth.
    ChemMedChem. 2016 Oct 6;11(19):2205-2215. DOI: 10.1002/cmdc.201600343.


    G Ricci C, Liu YL, Zhang Y, Wang Y, Zhu W, Oldfield E, McCammon JA.
    Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
    Biochemistry. 2016 Sep 13;55(36):5180-90. DOI: 10.1021/acs.biochem.6b00398.

    (c) 2010-2015 Research Group of Professor Eric Oldfield
    University of Illinois at Urbana-Champaign

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