• Nature Reviews Drug Discovery
  • NIH Research Matters
  • Press Release (Malaria)
  • Press Release (IKK2)
  • Nature Cell Biol. (IKK2)
  • Press Release/Staph
  • C&EN News: Diterpene Cyclase
  • Nature Chem. Biol. on CrtM
  • 2011 Biophysical Society Award
  • C&EN News on 4Fe4S Cluster
  • Accounts of Chemical Research
  • PNAS: IspG
  • Jordan Gets ACS Scholarship Award
  • IspH PNAS in Microbe Magazine
  • Illinois News Bureau
  • RSC Award
  • C&EN
  • Chagas Clinical Results in Microbe Magazine
  • Our Pre-clinical Chagas Paper
  • Naked Scientists Podcast about Staph inhibitor
  • Nature Reviews Drug Discovery
  • New England Journal of Medicine


    Welcome Bienvenidos Welcome
    Swagatam Swagatam Welcome
    Our interests are to use XRD, computational chemistry, NMR, and synthesis to develop new antibiotics, anti-parasitics, and anti-cancer drugs.

    • Anti-Parasitics
    • NRC Rankings
    • Membrane NMR
    • Julio Urbina T. cruzi
    • Quantum Proteins
    • Bisphosphonate Mechanism
    • NO-Heme DFT
    • Dual Inhibitors
    • CrtM Mechanism
    • IPPI
    • Anti-Bacterials
    • Fuel Cell EC NMR
    • Pt-Rh EC NMR
    • Structure Refinement
    • UPPS Structure
    • Malaria No More
    • Actonel Chagas
    • LytB(IspH) Structure
    • Bone-Binding
    • Inorganic Solisd

    Latest 10 Publications


    Rao G, ODowd B, Li J, Ke Wang, Oldfield E.
    IspH–RPS1 and IspH–UbiA: “Rosetta stone” proteins.
    Chem. Sci., 2015, Advance Article. doi: 10.1039/C5SC02600H.


    Yang G, Zhu W, Kim K, Byun SY, Choi G, Wang K, Cha JS, Cho H-S, Oldfield E, No JH.
    Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates: An In Vitro and In Vivo Investigation.
    Accepted manuscript posted online 21 September 2015. doi: 10.1128/AAC.01873-15.


    Yang G, Zhu W, Wang Y, Huang G, Byun S, Choi G, Li K, Huang Z, Docampo R, Oldfield E, No JH.
    In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei.
    ACS Infect. Dis., 2015, 1 (8), pp 388–398. doi: 10.1021/acsinfecdis.5b00068.


    Farha MA, Czarny TL, Myers CL, Worrall LJ, French S, Conrady DG, Wang Y, Oldfield E, Strynadka NC, Brown ED.
    Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase.
    Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11048-53. doi: 10.1073/pnas.1511751112.


    Li K, Wang Y, Yang G, Byun S, Rao G, Shoen C, Yang H, Gulati A, Crick DC, Cynamon M, Huang G, Docampo R, No JH, Oldfield E.
    Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors.
    ACS Infect Dis. 2015 May 8;1(5):215-221.doi: 10.1021/acsinfecdis.5b00026.


    Saad A, Zhu W, Rousseau G, Mialane P, Marrot J, Haouas M, Taulelle F, Dessapt R, Serier-Brault H, Rivière E, Kubo T, Oldfield E, Dolbecq A.
    Polyoxomolybdate Bisphosphonate Heterometallic Complexes: Synthesis, Structure, and Activity on a Breast Cancer Cell Line.
    Chemistry. 2015 Jul 13;21(29):10537-47. doi: 10.1002/chem.201406565.


    Oldfield E.
    Tuberculosis terpene targets.
    Chem Biol. 2015 Apr 23;22(4):437-8. doi: 10.1016/j.chembiol.2015.04.004.


    Quitterer F, Frank A, Wang K, Rao G, ODowd B, Li J, Guerra F, Abdel-Azeim S, Bacher A, Eppinger J, Oldfield E, Groll M.
    Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [Fe4S4] Enzyme IspG (GcpE)
    J Mol Biol. 2015 Jun 19;427(12):2220-8. doi: 10.1016/j.jmb.2015.04.002.


    Liu YL, Cao R, Wang Y, Oldfield E.
    Farnesyl Diphosphate Synthase Inhibitors With Unique Ligand-Binding Geometries.
    ACS Med. Chem. Lett., Article ASAP. doi: 10.1021/ml500528x.


    Veiga-Santos P, Li K, Lameira L, de Carvalho TM, Huang G, Galizzi M, Shang N, Li Q, Gonzalez-Pacanowska D, Hernandez-Rodriguez V, Benaim G, Guo RT, Urbina JA, Docampo R, de Souza W, Oldfield E.
    SQ109: A New Drug Lead for Chagas Disease.
    Antimicrob Agents Chemother. 2015 Jan 12. pii: AAC.03972-14. [Epub ahead of print]. doi:10.1128/AAC.03972-14.

    (c) 2010-2015 Research Group of Professor Eric Oldfield
    University of Illinois at Urbana-Champaign

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